A Revolutionary erapy Diamagnetic therapy

BUILT ON FUTURE TECHNOLOGY PERISO mission is that of conjugating innovative ideas with the development of modern technologies, which effectively support the diagnostic and rehabi- litative medicine, without any invasive approach . DIAMAGNETIC THERAPY HEALTH AND SCIENCE ANTONIO SANTOLI - CEO PERISO SA means interdisciplinary research, effectively combined with the applied research of different science field.

our strength lies on Research, as a strategic resour- ce for physicians and healthca- re professional dedicated to the therapy and rehabilitation of patients. Successful applied science is our priority. Technology, developed in com- plete synergy with the opera- tor’s experience, which leads us to create new tools that gua- rantee rapid and successful tre- atment in complete safety. Innovation, carefully designed in support of human experien- ce, and the enrichment of pro- fessional training within the medical field, for a better rela- tionship terapist - patient.

Diamagnetic therapy is a non-invasive therapeutic method based on the repulsion mechanisms generated by the forces of high intensity magnetic fields. When subjected to the action of a magnetic field, the electronic structure of diamagnetic materials undergoes molecular movement in opposite direction to the field itself. High intensity magnetic fields can trigger cellular re-adaptation to positive physiological response in many pathologies affecting the muscular-skeletal system and significantly reduce treatment times while improving in the quality of life for patients. Also known as DMA (diamagnetic molecular acceleration) , diamagnetic therapy offers an original way to provide drug treatment that allows the completely painless administration of active principles without the use of needles or electric current. The use of diamagnetic materials combined with the effect of the magnetic field. High intensity magnetic fields as an innovative therapeutic instrument. Administering drugs through the DMA system eliminates the need to resort to traditional systems. Diamagnetic therapy Designed with future technology

Ferromagnetic substances are at- tracted to an external magnetic field. Unlike diamagnetic and pa- ramagnetic substances, a ferroma- gnetic material’s relative magnetic permeability is not constant when fields are varied. Relative magnetic permeability (µr) is related to vacuum magnetic perme- ability (µ0) in order to represent the ease with which magnetic forces pro- pagate in a vacuum. The repulsive force generated by the diamagnetic effect is very weak and is appreciable only when the magne- tic field is very intense. µr >0 ferromagnetic µr= 0 paramagnetic µr <0 diamagnetic m agnetic properties of materials Substances defined as paramagne- tic remain neutral in the presence of an external magnetic field because the respective forces of attraction and repulsion balance each other out. When a diamagnetic substance is invested in a magnetic field, it reacts by weakening the external field with a slight magnetic move- ment in the opposite direction to the field itself, in this way creating an effect of repulsion. Materials and substances are classified on the basis of their magnetic properties as ferromagnetic, paramagnetic, and diamagnetic. The physical characteristics of the latter constitute the foundation of diamagnetic therapy.

The physics of high intensity and low frequency magnetic fields, combined with the selective amplitude of the field’s gradient is the technological basis of diamagnetic therapy. HIGH INTENSITY: 2 Tesla It produces the diamagnetic effect Why 2 Tesla? Because the diamagnetic effect on water molecules that triggers the movement of liquids is made possible by the magnetic field’s high intensity. No, it isn’t, because the field’s 7Hz frequency is very low, therefore the energy generated is not ionizing and does not damage tissue. A magnetic field’s electric current is generated completely inside the tissue and is isotropic, or rather, equal in every one of its points, both at the surface and deep down. Isn’t a magnetic field of such high intensity dangerous? How does an electric current generated by a magnetic field differ from the electric current generated by a radio frequency? LOW FREQUENCY: 7 Hz It avoids damages of biological tissue YES, OF COURSE, BUT... SELECTIVE AMPLITUDE: adjustable It allows selective stimulation of tissues

The characteristics of intensity of the magnetic field and the pulse emission mode make diamagnetic therapy different from conventio- nal magnetic therapy. “Electromagnetism is something impalpable. Our senses perceive only an infinitely minute part of the order of less than one trillionth. This means that if the electromagnetic spectrum were an entire stretch of beach, we would perceive the existence of just one grain of sand. Yet that infinitely tiny band of the spectrum gives us some of the deepest emotions of our lives: a sunset, the specta- cular colors of a flower, a beloved person’s face. I can’t even imagine how it would be to appreciate even only a little bit more. However, the other areas of the spectrum are no less important for us, and assist us in our day to day lives, making the telephone, television, and internet work, curing us of disease. From the immense magnitude of the electromagnetic spectrum, humans have fashioned instruments ca- pable of “seeing” all the way from nanometers (0.000,000,001 m) to hundreds of thousands of kilometers (300,000,000 m); here, the CTU occupies a special, far from anonymous place on the electromagnetic spectrum, a place where functional structures of our body can ”feel” its effects. And that’s where it belongs!” The Inventor M AGNETOTHERAPY Just a conductor of the electrical flow the role of the water element Field intensity Effect on liquids treatment of pathology in the acute phase Average time per session Selective apmlitude adjustable Average of treatment sessions Basic costituent of the therapy 100 gauss 20.000 gauss NO yes NO yes 4 hours 15 minutes (Non-selective current) NO YES (Selective current) 45 15 D IAMAGNETIC THERAPY

CTU CTU mega DIAMAGNETIC PUMP 20 20 Diamagnetic therapy technology and tools

Power supply 50-60 Hz 230 V corrent consumption 9,5 A power consumption 2200 VA (800 W) Conversion factor 0,36 operating frequency 1 Hz – 7 Hz Type of emission impulse Atmospheric pressure from 700 to 1000 hPa cooling system liquid dimension 84 x 80 x 163 cm weight 100kg - indicative operating room temperature from 10 °C to 30 °C field generator electromagnetic coil The technology is safe because the energy associated with the field is too weak to break molecular bonds. CTU mega 20 diamagnetic pump Digital display Touch Screen Diamagnetic Complex Cream Neutral conductive lotion formula- ted to heighten electric conductan- ce. Diamagnetic Handpiece The CTU Mega 20 magnetic field has a high intensity of up to 2 Tesla with a gradient <400T/s. The intensity of the field generates a visible diamagnetic effect on the materials; the elevated gradients induce current in the tissues. The possibility to modulate the magnetic field’s gradient also permits the generation of a wide frequency range in the current induced in biological tissue. Thanks to the diamagnetic effect, the magnetic field generated by the CTU Mega 20 is capable of influencing body fluid dynamics. T echnical Features

Diamagnetic therapy Mechanisms of action Water is one highly diamagnetic substance, but so are many other organic substances, such as lipids and most plasma proteins, which play key roles in human metabolism. The repulsive mechanical force exerted by diamagnetic therapy interacts with these substance at both extracellular and intracellular level, promoting the resolution of edema and tissue healing processes. MOVEMENT OF LIQUIDS ENDOGENOUS BIOSTIMULATION PAIN CONTROL ADMINISTRATION AND MOLECULAR IMPLANT

The degree of interaction between the diamagnetic pump and the human body’s fluid compartments depends on the fact that the water is the medium in which all the body’s biological reactions take place. Intervening on the body’s water and electrolyte balance means interacting with the systems responsible for maintaining osmotic pressure and electric potential, two aspects that are fundamental in many physiological functions such as neuromuscular activation and nerve impulse conduction. The main effects of diamagnetic therapy on the extracellular and intracellular matrix regard the activation of the following fundamental biological functions: • fluid drainage • nutrient and metabolite transport • cellular homeostasis modulation • tissue stimulation CTU mega 20 diamagnetic pump Diamagnetic therapy acts on the intracellular and extracellular matrix, producing drainage, rege- neration, and strong tissue biosti- mulation. M ovement of liquids

CTU mega 20 diamagnetic pump Diamagnetic therapy stimula- tes biological tissue thanks to the effects of the electric field induced inside the cell membranes and en- do-cytoplasmic structures that are charged with electric potential as a result. This stimulation is endogenous and isotropic, meaning that it is generated inside the organism and distributed evenly on both the surface and deep down inside for the entire volume of the magnetic field’s interaction. The high variation speed of the CTU Mega 20 magnetic field and its intensity up to 2 Tesla permits the energization of even the deepest levels of tissue, and not only on the surface. Adjusting the amplitude of the magnetic field, it will generate a wide range of frequency that allows the stimulation of targets more selectively. Variations in the frequency and shape of the magnetic pulse permit action to be taken selectively in different areas to be treated and tissue to be energized by wavelengths corresponding to the phisiological level. Physiological stimulation frequencies: Smooth muscle: up to 50 Hz Striated muscle: up to 100 Hz Nervous tissue (slow-twitch fibers): up to 1,000 Hz Nervous tissue (fast-twitch fibers): up to 5,000 Hz Cellular action: up to 7,500 Hz Membrane action: up to 10,000 Hz Tendon tissue: above 10,000 Hz e NDOGENOUS BIOSTIMULATION

CTU mega 20 diamagnetic pump Unlike other electric current methods, diamagnetic therapy, which uses the magnetic field, does not cause tissue polarization or the hydrolysis of pharmacological substances. With the CTU Mega 20, drug molecules can be trans-cutaneously administered using the repulsive mechanical force imparted by the magnetic field. The diamagnetic molecular implant follows a linear curve with Gaussian distribution at any given depth. The desired layering of the active principle can be obtained on the basis of the volume of the pharmaceutical product and the depth of implant. With conveyance by means of electrical current instead, substances are unevenly distributed throughout the tissues and subject to saturation because diffusion occurs exponentially. A 215 KHz frequency induced in tissues by diamagnetic therapy permits selective action also on pain nerve receptors and trigger points using the pain control function either as a single treatment or as part of a multiple treatment regimen. Which pharmaceuticals can be ad- ministered by molecular implant? All pharmaceuticals with diamagnetic properties or those that can be dissolved in the water used as an excipient can be given. All substances in watery solutions can be directly used by the system. traditional implant c: concentration of active principle p: depth of penetre- tion of tissue implant with CTU m olecular implant p ain control YES, OF COURSE, BUT... The use diamagnetic therapy permits tissue barrier to be passed trough to a depth of 7 cm for the implant of the active princple.

Magnetic Field + Radiofrequency Efecto Push and Pull The CTU Mega 20 diamagnetic pump is designed to permit the use also of an electric generator that generates a radiofrequency that can be used in capacitive or resistive mode. Therefore, with the CTU Mega 20 diamagnetic pump, the magnetic field can also be associated with diathermy for a special technique based on the so-called “push and pull” effect, a synergic combination of diamagnetic therapy and diathermy. Under normal operating conditions, the increased arterial and venous blood flows induced by the diathermic process undergo saturation due to vasodilatation when the physical limitation imposed by the mechanical conﬁnement of the external compartment is reached. This limitation can be overcome thanks to the repulsive force generated by the magnetic field, which induces the drainage of the liquids from the area in question. Capacitive Magnetic generator Magnetic field 2 tesla Electric field Traditional radiofrequency Electric generator It releases more energy into the first layer, just beneath the electrode. It releases more energy into the biological tissue with high impedence. Resistive P ush and pull effect The magnetic field generated by the CTU Mega 20 can be used autonomously, whereas radiofre- quency can be used only when ac- companied by the magnetic field. CTU mega 20 diamagnetic pump

DOUBLE NEUTRAL PLATE IMPEDANCE METER The use of the double neutral permits the treatment of extensive areas of the body while maintaining the balance and uniformity of the energy administered, with the advantage of reducing treatment times and accelerating therapeutic effects. In every treatment with diathermy, the device autonomously enables a system for the monitoring of variations of electric impedance in tissues which are generally linked to local metabolic conditions. By recording these variations in electrical impedance, the system provides real-time information on tissue response to treatment. What are the differences with traditional diathermy? Traditional diathermy does NOT involve the use of a magnetic field generator, but only a normal electric generator whose therapeutic function is based exclusively on radiofrequency. It is the combined use of an electric generator and a magnetic field generator that enables therapeutic treatment that associates normal diathermy action with diamagnetic therapy action, in this way generating the “ push and pull ” effect. Synergic Interaction Push and pull effect Electric field 470KHz Magnetic field 20.000 Gauss Traditional radiofrequency DIAMAGNETIC THERAPY t echnological innovation CTU mega 20 diamagnetic pump The CTU Mega 20 generates a 470 kHz radiofrequency. Techno- logical innovation permit the op- timum use of diathermy for every type of treatment. Yes, of course, but...

Diamagnetic therapy Fields of application ORTHOPEDICS AND TRAUMATOLOGY: muscle and tendon lesions, degenerative pathologies of the bone and joint system, fractures and pseudoarthrosis, vascular bone pathologies RHEUMATOLOGY: in rheumatic and inflammatory conditions. PHYSIATRICS: as a supplement to rehabilitative therapy and prevention treatments for muscular-skeletal system pathologies and neurologic disorders. SPORTS MEDICINE: osteitis pubis, tendonitis, contractures and muscle tears, sprains and contusions. PHLEBOLOGY AND ANGIOLOGY: lymphatic, inflammatory and post-traumatic edema. DERMATOLOGY AND AESTHETIC MEDICINE: in exposed skin lesions (sores and ulcers) for faster tissue regeneration. PAIN MEDICINE AESTHETIC MEDICINE

CTU mega 20 diamagnetic pump When set with the right parameters, the four mechanisms of CTU Mega 20 action permit the treatment of various pathologies in their various phases of evolution. Patient: A.T.; Gender: female; Age: 37 years ; Profession: nurse; Diagnosy: severe herniated discs, with inability to per- form any work; Medical prescription: surgery intervention; “ After the twenty-third treatment with the diamagne- tic pump, the patient no longer presented any symptoms of herniated disk. After the twenty-fifth treatment, the patient resumed his previous activities without any pro- blem.” dr. P. Laudikos Sagittal projection Before Cervical pain Achilles tendinopathy Popliteal tendonitis Patellar tendinopathy Sagittal projection After m ri co red

Completion technology: Enhancing your therapeutic process

CTU s wave diamagnetic shock wave The shock wave is produced by an interaction between the electromagnetic coil field flow and an acoustic lens composed of a hi- ghly diamagnetic alloy. Classic shock wave generators produce only one wave shaper and for such reason do not permit the adaptation or modulation of space gradients as required by the pathology, depth of treatment, and anatomical area. The CTU S Wave diamagnetic generator permits intervention on wave spatial gradients through the use of special acoustic lenses whose wave focus capacity recalls the Fresnel lens principle. CTU S Wave combines the effects of the energy component induced by the pressure field linked to the shock wave with diamagnetic repulsion effects, associating biostimulation action with a drainage effect that permits an acceleration of treatment times for optimized recovery times. CTU S Wave permits the simultaneous adjustment of both energy flow density and shock wave rise time modifying the space-time profile of the impulses emitted on the basis of the anatomic-pathological lesion in question and the tissue’s characteristic of acoustic impedance. THE FIRST SHOCK WAVE WITH A DIAMAGNETIC GENERATOR Completely painless

The primary effects of the CTU V Wave regard the muscle stren- gthening, trophism, and recovery. The device can also be used to prevent reductions in muscle mass associated with aging. CTU V wave vibration training MECHANICAL VIBRATION THERAPY Controlled vibration induces involuntary muscle contractions and de-contractions with the relative neurological response. CTU V Wave is equipped with a built-in electro-myo- graph reader that measu- res the echo produced by the spinal reflex arc. On the basis of the muscle response checked by the EMG sy- stem and the treatment objectives established, the CTU V Wave device modulates and adapts vibration frequencies in order to produce a randomized acoustic spectrum that annuls the effect of muscle inurement. By monitoring muscle response, the CTU V Wave permits a real-time check on the acoustic impedance of the coupling between tissue and generator, and consequently the modu- lation of the energy reflected by the stationary waves, in this way optimizing vibratory action. EMG BIO-FEEDBACK IDENTIFY THE BEST THERAPEUTIC FREQUENCY

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